print[a] School of Health Science, The University of South Australia, South Australia, Australia [b] Department of Obstetrics and Gynecology, The University of Adelaide, Adelaide, South Australia, Australia [c] Research Centre for Reproductive Health, The Queen Elizabeth Hospital, University of Adelaide, Adelaide, South Australia, Australia [d] Repromed, Adelaide, South Australia, Australia
Received 15 September 2005; received in revised form 10 December 2005; accepted 10 December 2005 published online 4 April 2006.
Objective
To evaluate the effects of acupuncture on clinical pregnancy rates for women undergoing ET.
Design
Single-blind, randomized controlled trial using a noninvasive sham acupuncture control.
Setting
Repromed, The Reproductive Medicine Unit of The University of Adelaide.
Patient(s)
Women undergoing IVF.
Intervention(s)
Women were randomly allocated to acupuncture or noninvasive sham acupuncture with the placebo needle. All women received three sessions, the first undertaken on day 9 of stimulating injections, the second before ET, and the third immediately after ET.
Main Outcome Measure(s)
The primary outcome was pregnancy. Secondary outcomes were implantation, ongoing pregnancy rate at 18 weeks, adverse events, and health status.
Result(s)
Two hundred twenty-eight subjects were randomized. The pregnancy rate was 31% in the acupuncture group and 23% in the control group. For those subjects receiving acupuncture, the odds of achieving a pregnancy were 1.5 higher than for the control group, but the difference did not reach statistical significance. The ongoing pregnancy rate at 18 weeks was higher in the treatment group (28% vs. 18%), but the difference was not statistically significant.
Conclusion(s)
There was no significant difference in the pregnancy rate between groups; however, a smaller treatment effect can not be excluded. Our results suggest that acupuncture was safe for women undergoing ET.
